فهرست:
مقدمه. 1
1-1- کلیات 1
1-2- تجهیزات کمکی بطن چپ(LVADs) 2
1-3- پدیدههای مهم در LVADها 3
1-4- تاریخچه و سیر تحول آشکارسازی پدیده مکش... 4
1-5- تاریخچه و سیر تحول طراحی کنترلرهای مربوطه. 5
1-6- سیر بررسی مطالب.. 7
سیستم قلب و مدل مربوط به آن.. 9
2-1- قلب و سیستم گردش خون. 10
2-1-1- قلب 10
2-1-2- سیستم گردش خون. 12
2-2- سیکل قلبی.. 15
2-2-1- بررسی برخی از مفاهیم اصلی.. 15
2-2-2- چرخه قلبی.. 18
2-3- مدل قلب.. 23
2-3-1- مدل مداری قلب.. 23
2-3-2- معادلات حالت.. 28
2-3-3- نتایج شبیه سازی.. 31
2-4- مدل قلب- پمپ.. 34
4-2-1- مدل قلب- LVAD.. 35
4-2-2- معادلات حالت.. 38
4-2-3- شبیهسازی حلقه باز 41
مساله آشکارسازی حالت مکش در LVAD.. 48
3-1- دیده مکش در LVAD.. 50
3-2- آنالیز شاخصهای مکش با استفاده از دبی عبوری از پمپ.. 54
3-3- شبیه سازی به همراه مدل قلب-LVAD.. 60
طراحی کنترلر تلفیقی Fuzzy-MPC برای سیستم قلب-LVAD 63
4-1- ساختار کنترلرهای مدل پیشبین.. 64
4-2- طراحی کنترلر تلفیقی پیشبین- فازی (Fuzzy-MPC) 66
4-2-1- کنترلر مدل پیش بین (Model Predictive Controller) 67
4-2-2- محاسبه کننده اندیس مکش (SI Calculator) 68
4-2-3- کنترلر فازی (Fuzzy Controller) 68
4-3- شبیهسازی.. 73
4-3-1- شبیهسازی برای قلب بیمار 73
4-4- بررسی میزان مقاومت کنترلر 78
5- نتیجهگیری و اهداف آینده 83
5-1- نتیجهگیری.. 83
5-1-1- مدل قلب و قلب - LVAD.. 84
5-1-2- آشکارساز حالت مکش... 84
5-1-3- کنترلر مدل پیشبین- فازی.. 84
5-1-4- شبیهسازیها 85
5-1-5- محدودیتها 85
5-2- اهداف آینده 86
منبع:
[1] Gu, M. and Qin, Y., “Development of left ventricular assist devices,” Intertional Journal of Cardiovascular Disease, 36(2): 69-71, 2009.
[2] http://www.americanheart.org/presenter.jhtml?identifier=4599
[3] Slaughter, M. S., Rogers, J.G., et al, “Advanced heart failure treated with cotinuous-flow left ventricular assist device,” The new England journal of medicine, Nov. 17, 2009.
[4] Vollkron, M., Schima, H., Huber, L., Benkowski, R., Morello, G., et al, “Development of a suction detection system for axial blood pumps,” Artificial Organs, 28(8): 709-716, 2004.
[5] Vollkron, M., Schima, H., Huber, L., Benkowski, R., Morello, G., et al, “Advanced suction detection for an axial flow pump,” Artificial Organs, 30(9): 665-670, 2006.
[6] Voigt, O., Benkowski, R.J. and Morello, G.F., “Suction detection for the micromed debakey left ventricular assist device,” ASAIO Journal, 51(4): 321-328, 2005.
[7] Ferreira, A., Chen, S., Simaan, M.A., Boston, J.R. and Antaki, J.F., “A discriminant-analysis-based suction detection system for rotary blood pump,” Proceedings of the IEEE EMBC, New York, USA, 5382-5385, 2006.
[8] Mason, D.G., Hilton, A.K. and Salamonsen, R.F., “Reliable suction detection for patients with rotary blood pumps,” ASAIO Journal, 54(4): 359-366, 2008.
[9] Wu, Y., Allaire, P., Tao, G., Wood, H., Olsen, D. and Tribble, C., “An advanced physiological controller design for a left ventricular assist device to prevent left ventricular collapse,” Artificial Organs, 27(10): 926-930, 2003.
[10] Vollkon, M., Schima, H., Huber, L., Benkowski, R., Morello, G., et al, “Development of a reliable automatic speed control system for rotary blood pumps,” The Journal of Heart and Lung Transplantation, 24(11): 1878-1885, 2005.
[11] Chen, S., “Baroreflex-based Physiological Control of a Left Ventricular Assist Device,” University of Pittsburgh, 2006.
[12] Chen, S., Ferreira, A., Simaan, M.A., Boston, J.R. and Antaki, J.F., “Feedback control of an LVAD supporting a failing cardiovascular system regulated by a baroreflex,” Proceedings of the 45th IEEE CDC, San Diego, CA, USA, Dec. 13-15: 655-660, 2006.
[13] Ferreira, A., “A rule-based controller based on suction detection for rotary blood pumps,” PhD. Thesis, University of Pittsburgh, Pittsburgh, PA, 2007.
[14] Ferreira, A., Boston, J.R., and Antaki, J.F., “A control system for rotary blood pumps based on suction detection,” IEEE Transactions on Biomedical Engineering, 56(3): 656-665, 2009.
[15] Simaan, M.A., Ferreira, A., Chen, S., Antaki, J.F. and Galati, D.G., “A Dynamical State Space Representation and Performance Analysis of a Feedback-Controlled Rotary Left Ventricular Assist Device,” IEEE Transactions on Control Systems Technology, 11(7): 15-28, 2009.
[16] http://www.zgxl.net/sljk/imgbody/xinzang.htm
[17] http://en.wikipedia.org/wiki/File:Heart_systole.svg
[18] http://en.wikipedia.org/wiki/File:Heart_diastole.png
[19] http://www.hudong.com/wiki
[20] Suga, H., Sagawa, K., “Instantaneous pressure-volume relationships and their ratio in the excised, supported canine left ventricle,” Circulation Research, 35(1): 117-126, 1974.
[21] Stergiopulos, N., Meister, J. and Westerhof, N., “Determinants of stroke volume and systolic and diastolic aortic pressure,” American Journal of Physiology, 270(6): 2050-2059, 1996.
[22] Simaan, M.A., “Modeling and control of rotary heart assist device,” Handbook of Automation, Ed S. Norf, Springer Verlag, 1409-1422, 2009.
[23] Schima, H., Trubel, W., Moritz, A., et al, “Noninvasive monitoring of rotary blood pumps: necessity, possibilities, and limitations,” Artificial Organs, 16(2): 195-202, 1992.
[24] Yuhki, A., Hatoh, E., Nogawa, M., Miura, M., Shimazaki, Y. and Takatani, S., “Detection of suction and regurgitation of the imiplantable centrifugal pump based on the motor current waveform analysis and its application to optimization of pump flow,” Artificial Organs, 23(6): 532-537, 1999.
[25] Morello, G.F., “Blood pump system and method of operation,” US Patent: 0215050, 2004.
[26] Karantonis, D.M., Lovell, N.H., Ayre, P.J., Mason, D.G. and Cloherty, S.L., “Identification and classification of physiologically significant pumping states in an implantable rotary blood pump,” Artificial Organs, 30(9): 671-679, 2006.
[27] K., M., “Central venous pressure and pulmonary capillary wedge pressure monitoring,” Indian Journal of anaesthesia, 46(4): 298-303, 2002.
[28] Klabunde, R.E., “Cardiovascular physiology concepts,” Lippincott Williams & Wilkins, 2005
[29] http://www.doctorsky.cn/surgery/20081029/51524.html
[30] George Faragallah*, Yu Wang*, Eduardo Divo+,*, and Marwan A. Simaan*, Fellow, IEEE, “A New Current-Based Control Model of the Combined Cardiovascular and Rotary Left Ventricular Assist Device” 2011 American Control Conference/ June 29 - July 01, 2011.
[31] Abdul-Hakeem H. AlOmari “Non-Invasive Modelling And Controlof Implantable Blood Pumps For Heart Failure Patients” The University of New South Wales (UNSW), Sydney, Australia/ March 2011.