پایان نامه اثر 3 و 6 هفته تمرین هوازی بر فاکتور های رشدی و التهابی کبدی متعاقب القای دوز های مختلف دوکسوروبیسین

فهرست:

فصل اول

1-1. مقدمه... 2

1-2. بیان مسأله... 3

1-3. اهمیت و ضرورت پژوهش... 6

1-4. اهداف پژوهش:... 9

1-4-1. هدف کلی... 9

1-4-2.اهداف ویژه... 9

1-5. فرضیه‌های پژوهش... 9

1-6. تعریف واژهها و اصطلاحات پژوهش... 10

فصل دوم

2-1. مقدمه... 14

2-2.  مبانی نظری پژوهش... 14

2-2-1. آنتراسایکلینها و تاریخچه... 14

2-2-2. دوکسوروبیسین به عنوان یک عامل درمانی... 17

2-2-3. سمیت ناخواسته دوکسوروبیسین... 20

2-2-4. سمیت ناخواسته دوکسوروبیسین در کبد... 23

2-2-5 .آناتومی و فیزیولوژی بافت کبد... 26

2-2-6.سرطان در کبد... 28

2-2-7. مکانیزم التهاب در سرطان... 29

2-2-8. ساختار و فیزیولوژی فاکتورهای التهابی... 31

2-2-8-1.  اینتر لوکین 10 (IL-10)... 31

2-2-8-2. اینترفرون گاما (IFNγ)... 33

2-2-9. دستگاه رشدی... 35

2-2-10. پروتئینهای متصل شونده به IGF.. 41

2-3. پیشینه پژوهش... 43

2-3-1. مطالعات دوکسوروبیسین در حیطه غیر ورزشی و ورزشی  43

فصل سوم

3-1. مقدمه... 56

3-2. روش پژوهش... 56

3-3. آزمودنی های پژوهش... 56

3-4. متغیرهای پژوهش... 59

3-4-1. متغیرهای مستقل... 59

3-4-2. متغیر وابسته... 59

3-5. تغذیه و محیط نگهداری حیوانات:... 59

3-6. ابزارهای مورد استفاده در پژوهش:... 60

3-7. برنامه تمرینی آزمودنیها... 61

3-8. نحوه تهیه و تزریق دوکسوروبیسین... 63

3-9. بافت برداری و آنالیز آزمایشگاهی... 64

3-10. روش تجزیه و تحلیل اطلاعات... 65

فصل چهارم

4-1. مقدمه... 67

4-2. تجزیه و تحلیل دادههای توصیفی... 67

4-2-1. فاکتور شبه انسولین  (IGF-1)... 67

4-2-2. پروتئین -1 متصل به IGF-1 (IGFBP-1)... 70

4-2-3. پروتئین-3 متصل به IGF (IGFBP-3)... 73

4-2- 4. نسبت IGF-1 بهIGFBP-3.. 75

4-2-5.  اینترفرون گاما... 78

4-2-6. اینترلوکین 10(IL-10)... 80

4-3. آزمون فرضیه های پژوهش... 82

4-3-1. آزمون فرضیه اول... 83

4-3-2. آزمون فرضیه دوم... 85

4-3-3. آزمون فرضیه سوم... 86

4-3-4. آزمون فرضیه چهارم... 88

4-3-5. آزمون فرضیه پنجم... 90

4-3-6. آزمون فرضیه ششم... 91

فصل پنجم

5-1. مقدمه... 95

5-2. خلاصه پژوهش... 95

5-3. بحث و بررسی... 100

5-3-2. بررسی IGFBP3.. 105

5-3-3. بررسی IL-10.. 107

5-3-4. بررسی تغییرات INF-γ.. 109

5-4. نتیجه گیری... 112

5-5. محدودیتهای پژوهش... 113

5-6. پیشنهادهای پژوهش... 113

5-6-1. پیشنهادات برخاسته از تحقیق... 113

5-6-2. پیشنهاد به محققان آتی... 114

منابع... 116

پیوست... 125

پیوست الف... 125

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