فهرست:
فهرست مطالب
عنوان صفحه
فصل اول
1-1. مقدمه. 2
1-2. بیان مسأله. 3
1-3. اهمیت و ضرورت پژوهش..... 6
1-4. اهداف پژوهش: 9
1-4-1. هدف کلی... 9
1-4-2.اهداف ویژه 9
1-5. فرضیه‌های پژوهش..... 9
1-6. تعریف واژهها و اصطلاحات پژوهش..... 10
فصل دوم
2-1. مقدمه. 14
2-2. مبانی نظری پژوهش..... 14
2-2-1. آنتراسایکلینها و تاریخچه. 14
2-2-2. دوکسوروبیسین به عنوان یک عامل درمانی... 17
2-2-3. سمیت ناخواسته دوکسوروبیسین... 20
2-2-4. سمیت ناخواسته دوکسوروبیسین در کبد.. 23
2-2-5 .آناتومی و فیزیولوژی بافت کبد.. 26
2-2-6.سرطان در کبد.. 28
2-2-7. مکانیزم التهاب در سرطان.. 29
2-2-8. ساختار و فیزیولوژی فاکتورهای التهابی... 31
2-2-8-1. اینتر لوکین 10 (IL-10). 31
2-2-8-2. اینترفرون گاما (IFNγ). 33
2-2-9. دستگاه رشدی... 35
2-2-10. پروتئینهای متصل شونده به IGF.. 41
2-3. پیشینه پژوهش..... 43
2-3-1. مطالعات دوکسوروبیسین در حیطه غیر ورزشی و ورزشی... 43
فصل سوم
3-1. مقدمه. 56
3-2. روش پژوهش..... 56
3-3. آزمودنی های پژوهش..... 56
3-4. متغیرهای پژوهش..... 59
3-4-1. متغیرهای مستقل... 59
3-4-2. متغیر وابسته. 59
3-5. تغذیه و محیط نگهداری حیوانات: 59
3-6. ابزارهای مورد استفاده در پژوهش: 60
3-7. برنامه تمرینی آزمودنیها 61
3-8. نحوه تهیه و تزریق دوکسوروبیسین... 63
3-9. بافت برداری و آنالیز آزمایشگاهی... 64
3-10. روش تجزیه و تحلیل اطلاعات.... 65
فصل چهارم
4-1. مقدمه. 67
4-2. تجزیه و تحلیل دادههای توصیفی... 67
4-2-1. فاکتور شبه انسولین (IGF-1). 67
4-2-2. پروتئین -1 متصل به IGF-1 (IGFBP-1). 70
4-2-3. پروتئین-3 متصل به IGF (IGFBP-3). 73
4-2- 4. نسبت IGF-1 بهIGFBP-3.. 75
4-2-5. اینترفرون گاما 78
4-2-6. اینترلوکین 10(IL-10). 80
4-3. آزمون فرضیه های پژوهش..... 82
4-3-1. آزمون فرضیه اول.. 83
4-3-2. آزمون فرضیه دوم. 85
4-3-3. آزمون فرضیه سوم. 86
4-3-4. آزمون فرضیه چهارم. 88
4-3-5. آزمون فرضیه پنجم.. 90
4-3-6. آزمون فرضیه ششم.. 91
فصل پنجم
5-1. مقدمه. 95
5-2. خلاصه پژوهش..... 95
5-3. بحث و بررسی... 100
5-3-2. بررسی IGFBP3.. 105
5-3-3. بررسی IL-10.. 107
5-3-4. بررسی تغییرات INF-γ.. 109
5-4. نتیجه گیری... 112
5-5. محدودیتهای پژوهش..... 113
5-6. پیشنهادهای پژوهش..... 113
5-6-1. پیشنهادات برخاسته از تحقیق... 113
5-6-2. پیشنهاد به محققان آتی... 114
منابع.. 116
پیوست.... 125
پیوست الف..... 125
منبع:
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